Laxai is the place for seamless integration from target validation to candidate selection under one roof. We offer our clients a wide range of integrated drug discovery and development solutions, with core expertise founded in synthetic, medicinal and process chemistry, further augmented by preclinical services including DMPK and toxicology.
Research Informatics & In-silico Drug Discovery
Laxai in-silico team excels in drug discovery design efforts in collaboration with medicinal chemistry, structural biology, biology and DMPK teams, by conducting molecular modelling studies – pharmacophore and QSAR modelling, protein structure-based drug design, ligand-based drug design, fragment-based drug design, homology modelling, docking & scoring, chemo-informatics analysis and de novo designs. The team extensively utilizes in-house expertise in software development, chemo-curation for driving molecular designs
Drug Metabolism & Pharmacokinetics
Laxai provides one stop destination for complete in vitro ADME assessment of compounds. Apart from in vitro studies we provide PK, PD and toxicological studies. Studies like RBC hemolysis assay and in vitro phospholipidosis assay also forms part of our toxicological services
Library design for Macrocyclic, Kinases, Proteases, Linkers of bioconjugation (anti-body, peptide drug-conjugates). Key intermediates synthesis. Multi-step synthesis and characterisation of target molecules. Synthesis of patent examples and reference compounds and metabolites. Custom synthesis of macrocyclics, reference standards & Impurity synthesis. Process development and cGMP manufacturing.